Two hematopoietic transcription factors, RUNX1 and FUBP1, control jointly the expression of c-KIT oncogene in pre-B lymphoblasts
“We are interested in the mechanisms involved in controlling the transcriptional activity of RUNX1, a key transcription factor in hematopoiesis. To date, we are the first to link RUNX1, a new functional cooperator essential for the self-renewal of hematopoietic stem cells, and an oncogene involved in cell proliferation. "
INSERM UMR1126, Saint-Louis, Paris
Impact of a gain-of-function mutation of Cxcr4 on hematopoiesis in mice
"By using a mouse model carrying a gain in function of Cxcr4, a mutation found in patients with WHIM syndrome, our study has highlighted a crucial role in the desensitization of Cxcr4 in maintaining the quiescence / cell cycle balance. murine hematopoietic strains (ST-HSC) as well as in their differentiation into multipotent then lymphoid progenitors. "
TWO ORAL COMMUNICATION AWARDS
CNRS UMR 7292, LNOx team, Tours
Study of NADPH oxidases in acute myeloid leukemia
“The homeostasis of reactive oxygen species (ROS), modulated by oxidizing and antioxidant systems, is crucial in acute myeloid leukemia (AML). We have characterized the expression and functioning of NADPH oxidases (NOX) in LAMs and have shown that their overall activity is important for the production of ROS as well as the proliferation of these cells. "
LBMC ; CNRS, ENS, INRA, Lyon
Drugs modulating stochastic gene expression affect the erythroid differentiation process
“We are studying the role of stochasticity in gene expression on the erythrocyte differentiation process. My project consists in experimentally modifying this variability with drugs. We were able to show, by an approach coupling mathematical modeling and experimental data, that by homogenizing the expression of genes between each cell, we did affect their ability to differentiate. "