21st CHO congress in Grasse (Alpes Maritimes)
from Sunday September 28 to Wednesday October 1, 2014
Sunday 28/09/2014. Session 1
Moderator: Michele Goodhardt
8:30 p.m. - 8:45 p.m .: Congress opening:
Véronique Maguer – Satta (President of CHO)
8.45 p.m. - 9.30 p.m .: Hartmut GEIGER (Ulm, Germany)
Keynote reading: "Hematopoietic stem cell aging: not a one way road"
Monday 9/29/2014, 9 a.m. - 11.45 a.m. Session 2
Moderators: Eric Soler - Estelle Duprez
9h - 9h45: Jean-Christophe ANDRAU (IGMM, Montpellier)
"TBA Dynamic of epigenetic landscape and regulatory elements in developing T-cells"
9:45 am - 10:00 am: Lauriane Scourzic (INSERM U1009, IGR, Villejuif)
“Oncogenic cooperation between DNA methylation regulators TET2 and DNMT3A in hematopoietic malignancies”
10h - 10h15: Agata Cieslak (INSERM U1151, Hôpital Necker, Paris)
"RUNX1, a novel V (D) J recombination cofactor in humans"
10.15 a.m. - 10.30 a.m .: Break
10.30 a.m. - 10.45 a.m .: Christelle Vincent-Fabert (UMR7258, CRCM, Marseille)
"Deciphering PLZF function in hematopoietic stem cells"
10.45 - 11 am: Samuel Collombet (INSERM U1024, IBENS, Paris)
"Logical modeling of immune cell specification and reprogramming"
11 a.m. - 11.45 a.m .: Connie BONIFER (Birmingham, UK)
"Aberrant chromatin programming in acute myeloid leukaemia"
Monday 29/09/2014, 3 p.m. - 6 p.m. Session 3
Moderators: Jean Soulier - Thomas Mercher
3 p.m. - 3:45 p.m .: Alain EYCHENE (Institut Curie, Orsay)
"Raf signaling in mouse melanocyte stem cell and melanoma"
3:45 p.m. - 4:00 p.m .: Marie-Pierre Arnaud (CNRS UMR6290, Rennes)
“Disruption of CD9 expression affects adhesion, migration, and actin polymerization through RAC1 signaling pathway in ETV6 / RUNX1 pre-B lymphocytes”
4 p.m. - 4:15 p.m .: Isabel Hidalgo (CNIC, Madrid, Spain)
“Bmi1 controls the hematopoietic stem cell niche maintenance”
4:15 p.m. - 4:30 p.m .: Break
4.30 p.m. - 4.45 p.m .: Maria De Grandis (CNRS UMR 7258, CRCM, Marseille)
"JAM-C: a new leukemic stem cell biomarker in Acute Myeloid Leukemia"
4.45 p.m. - 5.00 p.m .: Xavier Cahu (CEA, Fontenay aux Roses)
“Bone marrow adipocytes negatively imprint on T-cell acute lymphoblastic leukemia development”
5:00 p.m. - 5:15 p.m.: Bastien Laperrousaz (INSERM U1052, CRCL, Lyon)
“Impact of BCR-ABL expression on cell stiffness in a model of immature hematopoietic human cells”
5:15 p.m. - 6:00 p.m .: Radek SKODA (Basel, Switzerland)
"Stem cell dynamics and disease initiation in myeloproliferative neoplasms"
Monday 29/09/2014: 6.30 p.m .: Aperitif - Poster session
Monday 09/29/2014: 8 p.m .: Gala dinner
Tuesday 30/09/2014, 9 a.m. - 11.45 a.m. Session 4
Moderators: Michèle Souyri - Pierre Lutz
9 a.m. - 9:45 a.m .: Catherine ROBIN (Utrecht, The Netherlands)
"Sequential maturation process towards hematopoietic stem cell production in the mouse embryo"
9.45 a.m. - 10 a.m .: Carine Halfon-Domenech (CNRS UMR7622, UPMC, Paris)
"Could embryonic haematopoiesis be at the origin of oncogenesis in the Fanconi model? "
10h - 10h15: Georges Lacaud (CRUK, Manchester, UK)
“GFI1 proteins orchestrate the emergence of haematopoietic stem cells in the AGM through recruitment of LSD1”
10.15 a.m. - 10.30 a.m .: Break
10.30 a.m. - 10.45 a.m .: Eric Soler (INSERM U967, CEA Fontenay aux Roses)
"Control of developmentally poised erythroid genes by combinatorial corepressor actions"
10.45 am - 11 am: Thiago Maciel (INSERM UMR1163, Paris)
"An activin receptor IIA ligand trap correct ineffective erythropoiesis in b-thalassemia"
11 a.m. - 11.45 a.m .: Katrin OTTERSBACH (Cambridge, UK)
"Dissecting the niche of emerging haematopoietic stem cells"
Tuesday 30/09/2014: 12 noon: Lunch
Tuesday 30/09/2014: 1:30 p.m. - 3:15 p.m .: Grasse tour
Tuesday 30/09/2014, 3 p.m. - 7 p.m. Session 5
Moderators: Olivier Hérault, Frédéric Mazurier
3.30 p.m. - 4.15 p.m.: Laurent YVAN-CHARVET (INSERM U1065, Nice)
"Metabolic abnormalities in wasting syndrome"
4.15 p.m. - 4.30 p.m .: Urszula Sieranska (INSERM UMR967, CEA, Fontenay aux Roses)
“SCL / TAL1 expression levels modulate human HSPC location and surrounding niche in relation with hypoxia in the bone marrow”
4.30 p.m. - 4.45 p.m.: Cyril Quivoron (INSERM U985, IGR, Villejuif)
“AG-221, a potent IDH2 R140Q mutant inhibitor, induces terminal differentiation in a xenotransplant model. "
4.45 p.m. - 5.00 p.m .: Break
5:00 p.m. - 5:15 p.m.: Virginie Chesnais (INSERM U1016, Cochin, Paris)
"Study of the clonal architecture of MDS after ex vivo amplification of CD34 + CD38- progenitors"
5.15 p.m. - 5.30 p.m.: Marc Piechaczyk (CNRS UMR5535, IGMM, Montpellier)
"The ROS / SUMO axis is involved in chemosensitive acute myeloid leukemia (AML) cells response to chemotherapeutics and constitutes a potential target to overcome chemoresistance in AMLs".
5.30 p.m. - 6.15 p.m.: Stéphane Manenti (Toulouse)
"Cell cycle regulation and checkpoints in AML"
Tuesday 30/09/2014: 6.15 p.m. - 7 p.m .: GA
Tuesday 30/09/2014: 8 p.m .: Gala evening
Wednesday 10/01/2014, 8:30 a.m. - 11 a.m. Session 6
Moderators: Eric Delabesse, Françoise Porteu
8:30 am - 9:15 am: Jean SOULIER (IUH, Paris)
"Clonal evolution, tumor progression and relapse in leukemia"
9:15 am - 9:30 am: Marie-Anne Hospital (INSERM U1016, Cochin, Paris)
"Pim kinases modulate resistance to tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia"
9:30 am - 9:45 am: Dorothée Selimoglu-Buet (INSERM U1009, IGR, Villejuif)
“Down-regulation of miR-150 generates the accumulation of classical monocytes, a characteristic feature of chronic myelomonocytic leukemia”
9.45-10 am: Break
10h - 10h15: Aurore Hattabi (INSERM U1016, Cochin, Paris)
“Study of the post-transcriptional regulators Pumilio 1/2 in normal and pathologic hematopoietic stem / progenitor cells. "
10.15-11 am: David BRYDER (Lund, Sweden)
"Searching for the target cell in MLL-ENL driven AML"
11.15 - 11.30 a.m .: End of the congress