Program
Wednesday, October 14, 2015
5:30 -7:30 p.m : Registration and welcome cocktail
7:30 p.m : Supper
Wednesday, October 14, 2015. Session 1
Moderator : Véronique Maguer-Satta
9:00 - 9:15 p.m : Meeting opening :
Véronique Maguer–Satta (CHO president)
9:15 - 10:00 p.m : Tariq ENVER (UCL, London, UK)
Keynote lecture: Origins and Evolution of Childhood Leukaemia
Thursday, October 15, 2015. Session 2
Moderators: Thierry Jaffredo – Françoise Pflumio
8:30 - 9:15 a.m : Erika Brunet (Musée Nal D’Histoire, Paris)
Cancer translocations using genome-editing methods (CRISPR/Cas9) to understand oncogenesis
9:15 - 9:30 a.m : Bérengère De Laval (CIML, Inserm U1104, CNRS UMR7280, Marseille)
Differential proliferative response and early myeloid commitment of HSC depending on previous infection history
9:30 - 9:45 a.m : Marie-Laure Arcangeli (CEA-iRCM-INSERM U967, Fontenay-aux- Roses)
Effects of Low doses of ionizing radiations on human Hematopoietic Stem cell functions
9:45 - 10:00 a.m : Quickfire poster presentations. Session I
10:00 - 10:30 a.m : Break
10:30 - 10:45 a.m : Alessandro Donada (INSERM U1170, IGR, Villejuif)
Modeling of the pre-leukemic state in ANKRD26-thrombocytopenia by induced pluripotent stem cells
10:45 -11:00 a.m : Romain Aucagne (IRIC, Montréal, QC, Canada)
Centrosomal localization of BMI1 reveals a key role for Polycomb proteins in coordinating centrosome duplication and cell cycle progression
11:00 - 11:45 a.m : Ido Amit (Weizmann Institute of Science, Rehovot, Israel)
Shaping the blood: Lessons from chromatin and single cell RNA-seq dynamics
11:45 a.m : Lunch
Thursday, October 15, 2015. Session 3
Moderators: Michèle Souyri – Pierre Lutz
3:00 - 3:45 p.m :Thierry Jaffredo (UMR7622, UPMC, Paris, France).
Hemogenic endothelium during development and beyond
3:45 - 4:00 p.m : Carine Halfon-Domenech (CNRS UMR 7622, INSERM U1156, UPMC PARIS 6)
Exhaustion in myeloid lineage and very early defect in HSPC pool: an embryonic origin of Fanconi haematological disorders
4:00 - 4:15 p.m :Michèle Crozatier (CBD /UMR 5547 TOULOUSE III)
Vascular control of the Drosophila haematopoietic niche: role of Slit/Robo signalling
4:15 - 4:30 p.m : Quickfire poster presentations. Session II
4:30 - 5:00 p.m : Break
5:00 - 5:15 p.m : Marielle Balzano-Foucher (CRCM - Inserm U1068 - CNRS UMR 7258 Marseille)
Hematopoietic Stem Cell and early B cell differentiation programs depend on a unique multispecific perivascular niche
5:15 - 5:30 p.m : Grégoire Stik (CNRS UMR 7622, Inserm 1156, IBPS, UPMC Paris 6)
Roles of Exosomes in the Hematopoietic Stem Cell-Supporting Capacity of Stromal Cells
5:30 - 5:45 p.m : Elodie Grockowiak (Inserm U1052-CNRS UMR5286, Lyon)
BMP signalling deregulations persist in CML resistant patients under treatments and contribute to LSC persistence independently of BCR- ABL
5:45 - 6:30 p.m : Daniela Krause (Georg Speyer Haus, Frankfurt, Germany).
A hostel for the hostile : Characterising and therapeutic targeting of the leukaemic stem cell niche
6:30 p.m : Drinks – Poster session
8:30 p.m : upper
Friday, October 16, 2015. Session 4
Moderators : Michael Sieweke – Frédéric Mazurier
9:00 - 9:45 a.m : Eric Solary (U1170 INSERM, IGR, Villejuif, France)
Chronic myelomonocytic leukemia: strategies to improve diagnosis and care
9:45 - 10:00 a.m : Kevin Rouault-Pierre (Haematopoietic Stem Cell Lab, London)
Myelodysplastic Syndrome-Initiating Cells can propagate from Multipotent Progenitor compartment
10:00 - 10:15 a.m : Laetitia Saint Paul (Inserm U866, Dijon)
Localization of the CD45 phosphatase within lipid rafts is crucial for AML maintenance
10:15 - 10:45 a.m : Break
10:45 - 11:00 a.m : Florence Zylbersztejn (U1163/U1052, Lyon)
Vitamin D receptor controls stemness in acute myeloid leukemia
11:00 - 11:15 p.m : Cathy Ignacimouttou (INSERM U1170, IGR, Villejuif)
Deregulation of both ETO2 and GLIS2 functions in acute megakaryoblastic leukemia
11:15 - 12:00 a.m : Ruud Delwel (Erasmus, Rotterdam, Holland)
Molecular breakdown of acute myeloid leukemia with aberrant expression of EVI1 and GATA2
12:00 p.m : Lunch
1:30 - 3:30 p.m : Free time
Friday, October 16, 2015. Session 5
Moderators : Thomas Mercher – Olivier Hérault
3:30 - 4:15 p.m : Carmen Garrido (INSERM UMR866, Université de Bourgogne, Dijon).
HspPathies: role of HSP70 in erythropoietic disorders
4:15 - 4:30 p.m : Guillaume Giraud (Erasmus Medical Center, Rotterdam, Pays-Bas)
Fli-1 and the Ldb1 complex: A group of friends playing together during megakaryopoiesis and leukemia
4:30 - 4:45 p.m : Lucie Laplane (INSERM U1170, IGR, Villejuif)
CSC and Clonal Evolution, an Epistemological Investigation
4:45 - 5:00 p.m : Break
5:00 - 5:15 p.m : David Garrick (INSERM U1126, Saint Louis)
miR-125b-SUV39H1 pathway regulates heterochromatin and B lymphoid differentiation of human HSC with age
5:15 - 5:30 p.m : Cyril Esnault (IGMM, UMR5535 CNRS, Montpellier)
A chromatin modification cascade set the Ras-dependent immediate transcriptional program
5:30 - 6:15 p.m : Roger Patient (Radcliffe Department of Medicine, Oxford, UK).
Leukaemia-affiliated transcription factors, under the control of embryonic signals, drive HSC development
Friday, October 16, 6:15 - 7:00 p.m : AG
Friday, October 16, 8:00 p.m : Supper
Friday, October 16, 9:00 p.m : Reception
Saturday, October 17, 2015. Session 6
Moderators : Michele Goodhardt – Patrice Dubreuil
8:30 - 9:15 a.m : Brian J Huntly (CIMR, Cambridge University, Cambridge)
Epigenetic dysfunction in haematological malignancies
9:15 - 9:30 a.m : Coralie Hoareau-Aveilla (INSERM UMR1037 CRCT, Toulouse)
Reversal of microRNA-150 silencing disadvantages crizotinib-resistant NPM-ALK-positive cell growth
9:30 - 9:45 a.m : Enguerran Mouly (INSERM U1170, IGR, Villejuif)
Tet2 deficiency in mice a new model of CLL-like disease development
9:45 - 10:15 a.m : Break
10:15 - 10:30 a.m : Isabelle Plo (INSERM U1170, IGR, Villejuif)
Germline duplication of ATG2B and GSKIP predisposes to familial MPN and myeloid malignancies
10:30 - 11:15 a.m : Bertrand Nadel (CIML, Marseille, France).
Site- and allele-specific polycomb dysregulation in T-cell leukaemia
11:15 - 11:30 a.m : Award ceremony
End of meeting